A strong demand for alternative pain treatments has fueled significant growth in hemp-derived cannabidiol (CBD) products. Recommendations for CBD products by doctors in pain management clinics have increased in recent years. To collect real-world data via a national registry of U.S. patients with inflammation and pain who use CBD products, we have designed a knowledge network that facilitates this community of interest in gaining insights and building collaborative relationships to guide participates to valuable information resources, share best practices, improve outcomes, and exchange innovative thinking. By assessing participant needs, sharing resources, creating learning networks, and capturing patient reported outcomes, the conceptual model for the CBD Registry (CBDR) is based on three main principles: Principle 1: Assess: Our assessments includes three modules for capturing the data that provides participants (e.g., patients and providers) with a more engaged experience. Principle 2: Learn: Our framework includes three modules to deliver tailored information to better engage your participants: Education, News, and Resources. Principal 3: Share: The final core principle of the framework is a collection of modules designed to facilitate collaboration to foster sharing knowledge and best practices among participants (patients and providers): forums, events and experts.